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In low-income countries, the risk of female-to-male transmission is estimated as 0.38% per act, and of male-to-female transmission as 0.30% per act; the equivalent estimates for high-income countries are 0.04% per act for female-to-male transmission, and 0.08% per act for male-to-female transmission.

Sexual assault is also believed to carry an increased risk of HIV transmission as condoms are rarely worn, physical trauma to the vagina or rectum is likely, and there may be a greater risk of concurrent sexually transmitted infections.

The World Health Organization recommends treating all children less than 5 years of age; children above 5 are treated like adults.

Measures to prevent opportunistic infections are effective in many people with HIV/AIDS.

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Treatment recommendations for children are somewhat different from those for adults.

The mechanism of CD4 T cell depletion, although apoptosis may also be a factor.