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The War of 1812 cut off the supply of British goods, stimulating American industry.
By 1815, Pittsburgh was producing significant quantities of iron, brass, tin, and glass.
The French and Indian War, the North American front of the Seven Years' War, began with the future Pittsburgh as its center.
British General Edward Braddock was dispatched with Major George Washington as his aide to take Fort Duquesne.
Fort Pitt is notable as the site of an early use of smallpox for biological warfare.
Lord Jeffrey Amherst ordered blankets contaminated from smallpox victims to be distributed in 1763 to the tribes surrounding the fort.
General John Forbes finally took the forks in 1758.On March 18, 1816, the 46-year-old local government became a city.In the 1830s, many Welsh people from the Merthyr steelworks immigrated to the city following the aftermath of the Merthyr Rising.The nation's eighth-largest bank, eight Fortune 500 companies, and six of the top 300 U. law firms make their global headquarters in the Pittsburgh area, while RAND, BNY Mellon, Nova, Fed Ex, Bayer and NIOSH have regional bases that helped Pittsburgh become the sixth-best area for U. The error was repeated commonly enough throughout the rest of the 19th century that the original pronunciation was lost and in 1890 the "h" was removed in order to make it easier to spell.
After a public campaign the original spelling was officially restored by the United States Board on Geographic Names in 1911.Pittsburgh became a possession of Pennsylvania in 1785.